Application of FoxO1 gene in drug preparation

2014 
The invention belongs to the field of biological medicine and particularly relates to an application of a FoxO1 gene in drug preparation. According to the invention, the function of the FoxO1 gene in osteoblast proliferation differentiation under high sugar condition is researched so as to research the function of the FoxO1 gene in bone injury and osteoporosis induced by diabetes, in order to provide theoretical basis and experimental data for clinical treatment of diabetic bone injury and osteoporosis disease. The invention verifies that the FoxO1 gene can promote osteoblast proliferation, FoxO1 is used as a factor used for mainly regulating and controlling bone mass and has an antioxidant stress function on osteoblast, the FoxO1 gene generates a certain protection function on osteoporosis no matter in environment with increased oxidative stress level caused by ageing or diabetes or high blood sugar, and provides a new target for research and development of new anti-osteoporosis drugs.
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