P54 Positive role of continuous positive airway pressure for intensive care unit patients with severe hypoxaemic respiratory failure due to COVID-19 pneumonia: a single centre experience

P54 Table 1Comparison of respiratory parameters and laboratory biomarkers between continuous positive airway pressure responders and non-respondersCPAP responders (n= 14)CPAP non-responders (n= 9)P valueAge, mean±SD, years54±1254±180 89PaO2/FiO2 ratio prior to CPAP therapy, mean±SD, mmHg 84 5±16 0 83 9±23 00 94PaO2/FiO2 ratio change on CPAP therapy, mean±SD, mmHg +83 7±43 0 +82 4±40 0 95pH prior to CPAP therapy, mean±SD 7 47±0 037 49±0 040 39pH change on CPAP, mean±SD-0 02±0 02-0 04±0 030 11PaCO2 prior to CPAP therapy, mean±SD, mmHg 4 6±0 664 4±0 980 44PaCO2 change on CPAP, mean±SD, mmHg +0 23±0 4+0 51±0 420 13*Tidal Volume on CPAP, mean±SD, ml 475±179498±1860 80RR before CPAP therapy, mean±SD, minute-1 28±9 29±4 0 8 RR change on CPAP, mean±SD, minute-1 +1 6±7 0+0 9±9 10 84CRP, mean±SD, mg/L176±83274±630 01IL-6, median±IQR, pg/mL30±47139±1480 04D-dimer, median±IQR, ng/mL321±267 941±19900 001High sensitivity troponin, median±IQR, ng/L 11 0±4 29 7±34 00 57N/L ratio, median±IQR7 9±10 08 8±8 90 55Serum ferritin, mean±SD, ug/L1407±10791396±10560 9Abbreviations: CPAP= continuous positive airway pressure, SD= standard deviation, PaO2/FiO2 ratio= ratio of arterial oxygen partial pressure to fractional inspired oxygen, RR=respiratory rate, CRP= C-reactive protein, IL-6= interleukin-6, IQR= interquartile range, N/L= neutrophil/lymphocyte *Tidal Volume was recorded following CPAP initiation in 13 CPAP responders and 6 non-responders