Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia

Elisavet Chartomatsidou,Stavroula Ntoufa,Konstantia Kotta,Alessandra Rovida,Maria Anna Akritidou,Daniela Belloni,Elisabetta Ferrero,Theoni Trangas,Niki Stavroyianni,Achilles Anagnostopoulos,Richard Rosenquist,Paolo Ghia,Nikos Papakonstantinou,Kostas Stamatopoulos

Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia

2019

Elisavet Chartomatsidou
Stavroula Ntoufa
Konstantia Kotta
Alessandra Rovida
Maria Anna Akritidou
Daniela Belloni
Elisabetta Ferrero
Theoni Trangas
Niki Stavroyianni
Achilles Anagnostopoulos
Richard Rosenquist
Paolo Ghia
Nikos Papakonstantinou
Kostas Stamatopoulos

Key Points Microenvironmental stimuli affect EZH2 expression and function in CLL. Combined B-cell signaling and EZH2 inhibition showed synergistic effects on primary CLL cells.

Keywords:

Chronic lymphocytic leukemia
EZH2
Immune system
Cancer research
Medicine
Hematology
Signal transduction
Internal medicine
immune signaling

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