COMPARISON OF ANTEGRADE WITH ANTEGRADE/RETROGRADE CARDIOPLEGIA FOR MYOCARDIAL REVASCULARIZATION IN CORONARY ARTERY BYPASS GRAFTING

Background: Cardioplegia aimed to protect myocardial function during cardiac surgery and facilitate surgical procedures providing a quiet and bloodless operative field. Integrated cardioplegia offers superior myocardial protection of left ventricular free wall and septum compared with antegrade mode of cardioplegia delivery. Objective: To compare the post-operative myocardial protection indicators of antegrade cardioplegia and antegrade/retrograde cardioplegia during surgery in patients undergoing coronary artery bypass grafting surgery. Study Design: Prospective Cohort Study Setting: Department of Cardiac Surgery, National Institute of Cardiovascular Diseases, Karachi. Duration: 3rd August 2019 To 2nd February 2020 Material and Methods: 80 patients underwent CABG with antegrade/retrograde cardioplegia (exposed Group) and 80 patients with antegrade cardioplegia (unexposed Group) were included. Post inotropic Support and retained postoperative ejection fraction were obtained. Comparison between exposed and unexposed group was done applying chi-square test or fisher exact test. P-value ≤0.05 was considered as significant. Results: The mean postoperative ejection fraction was 50.43±9.25% in exposed group while in unexposed group it was 45.06±7.35% respectively. Total 52.5% patients were retained postoperative ejection fraction in exposed group and 26.3% patients in unexposed group while inotropic support were required for 72% patients in exposed and 25% in unexposed group. Significant association of study group with retained postoperative ejection fraction and inotropic support.