Absorption, tissue distribution and excretion of 19-deformyldesmycosin derivatives, new 16-membered macrolides, in mice

In this study we investigated the absorption, tissue distribution and excretion of the derivatives, 19-deformyldesmycosin (TMC-014), 19-deformyl-4″-deoxydesmycosin (TMC-015) and 19-deformyl-4'-deoxydesmycosin (TMC-016) in mice, and compared the results with those for the 19-formyl derivative, 4'-deoxydesmycosin