Towards the total synthesis of the labdane diterpenes Cacofurans A and B

Cacospongia sp. is a species of marine sponge that produces labdane-class diterpens known as Cacofurans A and B, which show cytotoxic activity in vitro. In this work, we present the synthetic pathway of Cacofurans A and B in ten and nine steps, respectively. Five steps of the synthetic proposal were completed, with 25% overall yield, including the formation of a five-membered ring using the Suarez reaction. After the completion of the total synthesis, the cytotoxic potential of Cacofurans A and B will be evaluated.