Poly (L Lysine) Mediated Delivery of Nucleic Acids

The concept of “complementary addressed oligonucleotides” as a tool to control specifically gene expression has been initially formulated by the group of Knorre and Vlassov as review in (1985). A first demonstration of a possible control of Rous sarcoma virus gene expression by synthetic oligonucleotides has been provided by Zamecnik and Stephenson (1978).