Second Lung Adenocarcinoma after Combination Chemotherapy in Two Patients with Primary Non-Hodgkin's Lymphoma

We report a rare complication of a secondary malignant solid tumor in two patients with non-Hodgkin's malignant lymphoma who developed lung adenocarcinoma after treatments with combination chemotherapies. The firstwas a case of primary malignant lymphoma of the cervical spinal cordwhich had beenpreviously treated with radiation to the spinal lesion and combination chemotherapies and entered complete remission. The patient wasfurther treated for relapse with autologous bone marrow transplantation preconditioned with high-dose chemotherapy. Lung adenocarcinoma developed 5.5 years after the initial diagnosis. The second case of malignant lymphoma of lymph nodesdid not respond to conventional combination chemotherapies and did not enter remission. Lung adenocarcinoma developed 1 year after the initial diagnosis. The two patients died of lungcarcinoma. The clinical profiles of thesecases are presented and the causal relationship of primary malignant neoplasms to the second malignant neoplasms is discussed.