Detection of endoscopic and histological inflammation after an attack of colonic diverticulitis is associated with higher diverticulitis recurrence.

Background & Aims: Colonic diverticulitis shows a high recurrence rate, but the factors associated with such recurrence are still unknown. �e aim of our study was to investigate the role of endoscopic and histological inammation as predictors for the recurrence of diverticulitis. Methods: One hundred and thirty patients suering from Acute Uncomplicated Diverticulitis (AUD) (81 males, 49 females, mean age 64.71 years, range 40-85) were prospectively assessed. All patients had AUD conrmed by computerized tomography (CT) and endoscopy. Clinical, endoscopic and histological follow- up was performed aer 6, 12 and thereaer 24 months aer diagnosis of AUD. Results: Sixteen patients were lost to follow-up. Diverticulitis recurred in 18 patients (13.84%): 15 (13.15%) patients showed recurrence of AUD, whilst 3 (2.63%) showed recurrence of complicated diverticulitis. At the end of the follow-up period, endoscopic inammation was still detected in 31 (27.67%) patients, and active histological inammation in 41 patients (36.6 %). Only detection of endoscopic and of histological inammation during the follow-up was a predictor of diverticulitis recurrence (Log rank test, p = 0.0004). Conclusions: Detection of endoscopic and histological inammation aer attack of AUD was identied as a predictor of diverticulitis recurrence.