Comparison of Micro-Ultrasound and Multiparametric MRI Imaging for Prostate Cancer: An International Meta-Analysis

INTRODUCTION AND OBJECTIVES:Multi-parametric MRI (mpMRI) is growing as a screening approach for prostate cancer due to trials such as PROMIS and PRECISION demonstrating high sensitivity and negative predictive values. Unfortunately, implementation of mpMRI programs is complicated in practice due to additional costs, complexity, learning curve, procedure time, and experience required for adequate interpretation and reproducible results. Many men are also contraindicated to MRI due to concerns with renal function, claustrophobia, or ferromagnetic implants. This work aims to compare the sensitivity and specificity of mpMRI with the novel high-resolution micro-ultrasound imaging modality, which maintains the workflow, simplicity and low cost of ultrasound and can be used to target biopsies in real-time without the need for MRI.METHODS:Data from 5 sites was aggregated, totaling 280 subjects presenting for ExactVu micro-ultrasound guided biopsy with available mpMRI studies. Samples in all subjects were taken fr...