Synthesis of Substituted Quinolines from N-Aryl-N-(2-alkynyl)toluenesulfonamides via FeCl3-Mediated Intramolecular Cyclization and Concomitant Detosylation.

Optimized conditions afford the target compounds via a 6-endo-dig cyclization/detosylation sequence and are suitable for the access to a diverse range of quinoline structures from simple starting materials.