Threonine Tyrosine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy

The spindle assembly checkpoint (SAC) maintains genomic integrity. A key component is threonine tyrosine kinase (TTK, also known as Mps1). TTK antagonism is hypothesized to cause genomic instability and cell death. Interrogating The Cancer Genome Atlas (TCGA) revealed high TTK expression in lung adenocarcinomas and squamous cell cancers versus the normal lung (P