PH-0332 The role of multidimensional evaluation in curative radiotherapy for elderly patients (aged ≥75)

Purpose or Objective The concept of frailty is a complex, multidimensional and cyclical state of vulnerability that has recognized as one of the most important issues in health care that can affect treatment approach and clinical outcomes. Despite the high cancer prevalence in elderly people, the optimal treatment for elderly patients remains challenging, due to the incidence of age-related pathologies that could affect patient's functional capabilities. In this contest, the aim of the study was the identification of frail patients, candidate for curative radiotherapy (RT) and to measure through multidisciplinary and multidimensional approach the impact of frailty on toxicities and outcomes. Materials and Methods A prospective observational study was designed in our Center for all patients with >75years, candidate for curative RT. Frail patients were identified by the radiation oncologist, before and at the end of RT, by Geriatric8 questionnaire (G8q). All frail patients (score grade 2 (RTOG). The G8q repeated at the end of RT resulted worse in 12 patients, while 7 patients showed a benefit from RT, reporting a G8 score improvement. Considering all patients, 9 no-frail patients reported a worse G8 score at the end of RT and 2 patients an improvement. Still now, only 6 vulnerable patients repeat the 6-month assessment and the G8 score resulted lower in all the patients (less 1-5 points). (Table presented.) Conclusion The number of elderly oncologic patients is progressively increasing and the importance of ensure older-person-centered care plans is growing day by day. This study is still ongoing. Preliminary results confirmed that G8q represents a simple tool to identify frail patients in daily practice, and that thanks to this evaluation most of elderly patients with indication to curative RT did not showed a fragile phenotype. Finally, the support of a multidisciplinary approach in vulnerable patients resulted useful in order to obtain their compliance to the treatment without increased toxicity.