Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China

We retrospective studied 27 consecutive patients who were confirmed 2019 novel coronavirus (2019-nCoV) infected pneumonia. 27 patients included 12 men and 17 women, with median age of 60 years (IQR 47-69). 17 patients discharged in recovered condition and 10 patients died in hospital. The median age of mortality group was higher compared to survival group (68 (IQR 63-73) vs 55 (IQR 35-60), P = 0.003). The comorbidity rate in mortality group was significantly higher than in survival group (80% vs 29%, P = 0.018), especially comorbid hypertension, diabetes, and cardiac disease. The predominant CT characteristics consisted of ground glass opacity (67%), bilateral sides involved (86%), both peripheral and central distribution (74%), and lower zone involvement (96%). A simple CT scoring method described before (Feng F, et al PloS one. 2014;9:e93885) was used. The median CT score of mortality group was higher compared to survival group (30 (IQR 7-13) vs 12 (IQR 11-43), P = 0.021), with more frequency of consolidation (40% vs 6%, P = 0.047) and air bronchogram (60% vs 12%, P = 0.025). Comparison of CT images between survival group (A-C) and mortality group (D-F) was shown in Fig1. In the receiver operating characteristic curve analysis, an optimal cutoff value of a CT score of 24.5 had a sensitivity of 85.6% and a specificity of 84.5% for the prediction of mortality.