CELLULAR AND MOLECULAR BASIS OF β-AMYLOID PRECURSOR PROTEIN METABOLISM

1. Abstract 2. Introduction 3. Discussion 3.1. βAPP Structure Gives Clues to its Function 3.2. βAPP is Trafficked and Processed Through the Secretory Pathway 3.3. α-Secretase Cleaves βAPP at the Cell Surface 3.4. Alternative βAPP Metabolism Gives Rise to s-Amyloid Peptides 3.5. Aβ Peptides may be Generated Intracellularly 3.6. FAD Mutations and the β-secretase 3.7. Role of Presenilin in Aβ Generation and AD Pathogenesis 3.8. Signal Transduction Regulates βAPP Trafficking 3.9. Hormonal Regulation of βAPP Metabolism 4. Perspective 5. Acknowledgement 6. References