Effects of incretin on bone metabolism

Literatures have been reported in recent years that incretin plays an important role in bone metabolism,mainly in promoting bone formation and inhibiting bone resorption,in addition to its effects on glucose metabolism.The mechanism is not clear,may be by affecting the expression of osteocalcin,osteoprotegerin/receptor activator of nuclear factor kappa-B ligand system and level of sclerosin.In addition,the action of incretin on advanced glycation end products,insulin,insulin-like growth factor,calcitonin and blood lipids may also affect bone metabolism. Key words: Incretin;  Bone metabolism;  Glucagon-like peptide-1;  Diabetes mellitus