Humanization of a mouse anti-human IgE antibody: a potential therapeutic for IgE-mediated allergies
1993
Mouse mAb TES-C21 (C21) recognizes an epitope on human IgE and, therefore, has potential as a therapeutic agent in patients with IgE-mediated allergies such as hay fever, food and drug allergies and extrinsic asthma. The clinical usefulness of mouse antibodies is limited, however, due to their immunogenicity in humans. Mouse C21 antidoby was humanized by complementarity detemining region (CDR) grafting with the aim of developing an effective and safe therapeutic for the treatment of IgE-mediated allergies
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