Predicting the Three-Dimensional Structure of Proteins by Homology-Based Model Building

A priori prediction of the 3-D structure of proteins remains an important unsolved problem. Of the theoretical methods employed today, only homology-based model building produces protein structures of sufficient accuracy to be of use in structure-function and related studies. The present work provides a discussion of the features of protein structure which bear on homology-based model building in addition to a detailed description of the homology-based approach, with examples drawn from our own work.