Простий метод оцінки темпу старіння для скринінгу здоров’я населення

Aging contributes to the development of a number of diseases, including cardiovascular disease and type 2 diabetes. Rapidly aging people have a high risk of developing age-related pathology. For the estimation of the aging rate the calculation of biological age is used. Biological age can both coincide with chronological age, and in this case aging is assessed as normal and physiological, or it can significantly exceed chronological age (accelerated aging). The aim of this study was to develop a simple method for estimating the rate of aging for population health screening. Methods. 165 practically healthy persons aged 18 to 87 years and 178 persons with hyperglycemia were examined. All individuals included in the study were assessed for anthropometric parameters, blood pressure and glucose tolerance. The inclusion criteria for the hyperglycemia group were fasting plasma glucose levels of 6.1 mmol/L and above or 2-hour glucose of 7.8 mmol/L and above on a standard glucose tolerance test. The formula for calculating the biological age was obtained through stepwise multiple regression. Results. The calculation of biological age in healthy persons according to the obtained formula showed that the standard prediction error was 11.1 years. Elevated glucose levels have been shown to be associated with increased aging in young and middle age, whereas after 60 years, the effects of hyperglycemia on the rate of aging disappeared. Conclusions. Our method of estimating the rate of aging is sufficiently accurate and can be used to assess the risk of age-related pathology in screening surveys.