Daptomycin analog and full solid phase synthesis preparation method thereof

The invention relates to a daptomycin analog and a full solid phase synthesis preparation method thereof. The full solid phase synthesis preparation method is technically characterized by comprising the steps of: linking a first Fmoc amino acid (Alpha-carboxyl thereof is protected by a selected group) to a solid phase resin carrier, wherein the side chain of the first Fmoc amino acid is provided with carboxyl; continuing to sequentially link 7 Fmoc amino acids, and sequentially removing Fmoc; linking a ninth Fmoc amino acid and removing Fmoc, wherein the side chain of the ninth Fmoc amino acid is provided with carboxyl (sulfydryl or amino) and the ninth Fmoc amino acid is protected by a selective group; continuing to sequentially link the subsequent 3 Fmoc amino acids and removing Fmoc; after linking fatty acid, selectively removing the protective group on the carboxyl (sulfydryl or amino) of the side chain of the ninth amino acid, then reacting with the carboxyl of the last Fmoc amino acid and removing Fmoc; after removing the protective group of the Alpha-carboxyl of the first amino acid, carrying out the cyclization on solid phase resin directly; and at last, cutting the product from the resin, and obtaining the product through the precipitation of cold ethyl ether.