Evolution of vascular brachytherapy over time: Data from the RENO-registry analysis☆

Abstract Objective To study the evolution of procedural variations in vascular brachytherapy (VBT) and their relationship to medium-term outcome. Methods and Results The RENO (European Surveillance Registry with Novoste Beta-Cath™) prospectively collected procedural and clinical outcome data on 1098 patients treated with VBT. Patients were divided for this analysis into Group-I, the first 50% registered, and Group-II, the last 50% registered. Shorter 30-mm source trains were more commonly used in Group-I ( p p =NS) and 60-mm ( p p p p There was significant drop in the incidence of geographic miss in Group-II (3.2% vs. 9%; p Conclusion There has been a learning curve and evolution of VBT techniques over time. In general, there has been an increase in radiation source length, use of cutting balloons, dwell time and radiation dose. This has resulted in significant reduction of geographic miss and a trend towards improve clinical outcomes. Continued development may result in further improvement in the treatment of patients with in-stent restenosis (ISR).