[Determination of liquid-crystalline transition temperature of temperature-sensitive liposomes of futraful by 1HNMR]

HNMR was employed to determine the liquid crystalline transition temperature ( T C) of the temperature sensitive liposomes of futraful. It is a method with high sensitivity, high accuracy and furnishing more information. The 1HNMR spectra were made and studied. The rate of peak height increase of phospholipid correlates to the thermotropic phase transition of liposomes. The study shows that the T C of DPPC liposomes and DSPC liposomes is 36℃ and 48℃, respectively. The T C of DPPC DSPC liposomes correlates with the proportion of the amount of DPPC and DSPC. The T C is not affected by futraful. The temperature sensitive liposomes of futraful with T C of 41℃ were prepared which consisted of 60% DPPC and 40% DSPC.