Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation

Gloss Learning and memory are thought to be supported by experience-dependent neuronal plasticity, which on a cellular level is expressed as long-term changes (such as potentiation or depression) of synaptic responses. Glutamate-gated ion channels known as AMPA receptors mediate basal neurotransmission. Their postsynaptic functional availability can be selectively modulated in correlation with a given stimulus. This review discusses the molecular basis of AMPA receptor trafficking to and anchoring at excitatory postsynaptic sites and their regulation by protein kinases.