A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults

Peter E. Morris,John T. Promes,Kalpalatha K. Guntupalli,Patrick Wright,Murray M. Arons

A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults

2010

Peter E. Morris
John T. Promes
Kalpalatha K. Guntupalli
Patrick Wright
Murray M. Arons

Introduction Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.

Keywords:

Randomized controlled trial
Intensive care medicine
Placebo
Antipyretic
Ibuprofen
Placebo-controlled study
Pharmacokinetics
Medicine
Anesthesia
hospitalized patients
critically ill
double blind
treatment outcome

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