Clinical analysis of gastric hyperplasia polyps with helicobacter pylori infection in pilot

Objective To study the therapeutic effects of eradicating helicobacter pylori (Hp) on the gastric hyperplasic polyps in military pilots.Methods Forty-six Hp infected patients with gastric hyperplasia polyps were averagely divided into eradication therapy group (treated by omeprazole,amoxicillin and levofloxacin or tinidazole) and control group (treated by omeprazole only).All patients were examined by gastroscopy before and 6,12,and 24 months after the treatments,meanwhile histopathological examination and Hp determination were done.Results By 24-month eradication therapy,the mucosal inflammation degree was significantly lower than that in control group (Z=-3.441,P＜0.01) and the elimination rate of gastric hyperplastic polyps reached 95.8％ comparing to 9.0％ in control group (x2 =31.401,P＜0.01).Conclusions The gastric hyperplastic polyps are closely related with Hp infection and the mechanisms may be related to gastric mucosal inflammation.The eradication of Hp would be helpful to the prevention and treatment of the gastric hyperplastic polyps for pilots. Key words: Helicobacter pylori;  Gastric mucosa;  Polyps;  Drug therapy