A facile approach to synthesize NH-3-aryloxindoles at room temperature by Rh(III)-catalyzed CH activation

Abstract The Rh(III)-catalyzed directed C H activation/carbenoid coupling reactions for the synthesis of NH-3-aryloxindoles is described. This mild, highly efficient and time-economical coupling reaction displays excellent functional group compatibility and regioselectivity. This methodology provided the straightforward way for the synthesis of NH-3-aryloxindoles, which might be of considerable bioactivities.