Ameloblastoma with stromal multinucleated giant cells
1994
We report a case of ameloblastoma which uniquely showed heavy-osteoclast-like giant cell accumulation and woven bone formation in the surrounding fibrous stroma. Immunohistochemistry showed that the giant cells were non-epithelial in origin and suggested that stromal factors (i.e. the presence or absence of mineralized bone) determines whether these cells express an osteoclastic antigenic phenotype.
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