Distribution and antibiotic resistance of Acinetobacter baumannii causing infection

OBJECTIVE To analyze the clinical distribution of Acinetobacter baumannii(ABA) and its drug resistance to common antibiotics,so as to provide evidence for reasonable clinical use of antibiotics.METHODS A.baumannii from clinical specimens obtained from the Second Affiliated Hospital of Nanjing Medical University were collected from Jan 2008 to Dec 2010,and the distribution of those isolates was studied and results of the drug susceptibility testing were analyzed.RESULTS A total of 1193 strains of ABA were detected,among the clinical specimens,the rate of the distribution in sputum was the highest(79.5%);the infections mainly distributed in ICU,accounting for 20.0%,followed by department of respiratory medicine(18.7%).The resistance rates of ABA to 14 antibiotics were relatively high and increased year by year to imipenem,meropenem,ceftazidime,and ticarcillin/clavulanic ticarcillin,the difference was statistically significant.CONCLUSION There is an increasing drug resistance of ABA to imipenem meropenem,ceftazidime,and ticarcillin/clavulanic ticarcillin,which may be related to the abuse of antibiotics;it reminds us to use antibiotics reasonably and strengthen the disinfection of hospital environment so as to reduce nosocomial infection.