THE CORRELATIONS BETWEEN PLASMA LEPTIN AND THE CONCENTRATIONS OF PROINFLAMMATORY CYTOKINES IN PATIENTS WITH TYPE II DIABETES MELLITUS IN MAINTENANCE HEMODIALYSIS

The goal of the study was to asses the serum level of leptin and to establish if there is a relationship between leptin and proinflammatory cytokines in diabetic and nondiabetic patients submitted to chronic hemodialysis. The study included 20 type II diabetic patients and 15 non-diabetic patients in maintenance hemodialysis. A group of 30 healthy age-matched subjects were used as control. The serum levels of leptin and inflammatory cytokines were determined: IL-6 (Interleukin 6), IL-8 (Interleukin 8), TNF-α (Tumor necrosis factor) before and after hemodialysis. The diabetic female patients on dialysis have leptin, TNF-α, IL-8 levels significantly higher than in control group (p 0.05). A negative correlation was detected only in diabetic female patients between serum ferritin and serum leptin (Pearson index -0.6062) and a positive correlation with BMI (Body mass index), (Pearson index 0.6657). Serum leptin levels in hemodialysed patients with type II diabetes mellitus do not differ significantly from those of hemodialysed non-diabetic patients. Rezumat Scopul studiului a fost de a evalua nivelul seric al leptinei si de a stabili dacă există o relaţie intre leptină si citokinele proinflamatorii la pacienţii cu diabet zaharat si fără diabet zaharat, hemodializaţi cronic. Studiul a inclus 20 de pacienţi cu diabet zaharat tip II si 15 pacienţi non diabetici hemodializaţi. Un grup de 30 de voluntari sănătosi cu vârste asemănătoare a fost folosit ca