Correlation between abnormal DNA methylation in CD4 + CD28-T cell and immune disease

CD4 + CD28-T cells are found in acute coronary syndrome and some autoimmune diseases.The characteristics of these cells include their cytotoxic potential,resistance to apoptosis and tissue-infiltrating capacity.The aberrant expression of genes in the CD4 + CD28-T cells might due to abnormal DNA methylation.These genes are closely related with the development of diseases.Further study on CD4 + CD28-T cell features and DNA methylation in diseaseswill,elucidate the pathogenesis of diseases and provide new clues for the treatment. Key words: CD4+CD28-T cell;  DNA methylation ;  Acute coronary syndrome;  Immune system diseases