Relación entre la expresión de antigenos ABH en cáncer de vejiga y carácter secretor. Comentario

The deletion of blood group ABO antigen in bladder carcinoma has attracted attention because of its potential as a prognostic parameter. Approximately 80% of subjects present H, A and B substances in the saliva and other secretions. The secretions of this substances is controlled by the secretor genes, Se and se. The term secretor is applied to those persons (genotype SeSe or Sese) who secrete H with or without A and B. The objective of this work was to investigate the relationship between ABH antigenic expression in urothelial cells and secretor character patients with bladder cancer. We examined 33 patients with bladder tumors and classified them in superficial and profound, plus 40 normal individuals. The secretor character was determined in saliva and the ABH urothelial antigens were performed in urinary sediment. The agglutination inhibition technique was used for these studies. The 80% of the normal population were secretors and all expressed ABH antigens in urinary sediment. The 30.31% of the patients with bladder cancer were non secretors, and 70% of them suffered deletion ABH antigens expression in urinary sediment. These findings indicate that there is a complex modulation of blood antigen biosynthesis associated with the neoplastic progression of the human urothelium.