The computation of simulated endplate potentials

A method is described for computing simulated subthreshold responses (i.e. endplate potentials) for the Falk--Fatt (1964) cable model of a muscle fibre due to a punctate change in ionic conductance. The method has been applied to a comparison of the Falk--Fatt and classical models. Comparison with experimental results suggests that the model is adequate to account for the response of the mouse muscle fibre, in which the endplate is highly localized. For frog muscle there are larger discrepancies, which may be due to the extended endplate in this species.