Abstract 20526: Adiponectin and High Sensitive C Reactive Protein are Reduced by Ether Low or High Intensity Exercise Training in Chronic Heart Failure: A Prospective Randomized Controlled Study

Background: Recent studies have shown that increased circulating levels of adiponectin (AD) and high sensitive C reactive protein (hs-CRP) were associated with higher mortality in chronic heart failure (CHF) patients (pts). Exercise training improves functional capacity, however, there are concerns regarding what exercise training intensity is better to improve inflammatory markers and overload hormones evaluated by brain natriuretic peptide (BNP) in CHF. Methods: 30 men, 54 ± 2 yrs (mean ± se), with non-ischemic dilated cardiomyopathy, functional class II-III, LVEF 28 ± 1%, peak oxygen consumption (VO2) = 17,4 ± 0,6 ml/kg/min were randomized into 3 groups: low intensity exercise training (LO) - 9 pts, high intensity exercise training (HI) -11 pts, and control (CO) - 10 pts, under optimal medical treatment. At baseline and at 6 months, all pts underwent maximal treadmill cardiopulmonary exercise testing, rest and peak BNP, rest hs-CRP and AD level and rest echocardiography (echo). Low intensity training w...