Let-7a microRNA levels in KRAS-mutated colorectal carcinomas determine survival differences in patients treated with anti-EGFR.

Emanuele Canestrari,A. Ruzzo,B. Vincenzi,N. Galluccio,Giuseppe Perrone,Francesca Andreoni,Paola Lorenzini,Eliana Rulli,S. Demidio,Catalano,Fotios Loupakis,Renato Bisonni,Irene Floriani,De Nictolis M,Donatella Santini,L. Salvatore,G. Tonini,Alfredo Falcone,Mauro Magnani,F. Graziano

Let-7a microRNA levels in KRAS-mutated colorectal carcinomas determine survival differences in patients treated with anti-EGFR.

2011

3635 Background: KRASis down-regulated by Let-7microRNA isoforms and this effect may be clinically relevant to patients harboring KRASmutations. We quantified the Let-7a isoform in KRAS-mutated col...

Keywords:

Pathology
KRAS
Cancer research
microRNA
Medicine
in patient

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