In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists.

Proton magnetic resonance spectroscopy (1H-MRS) has traditionally been used in the metabolic research of gliomas and its diagnostic value is well explored (1-9). Currently, however, 1H-MRS is used only as a supplemental tool to magnetic resonance imaging (MRI) in the diagnosis of gliomas (2, 5, 9). Such limited application of 1H-MRS in the diagnosis of gliomas can be attributed to the intrinsic low concentrations of metabolites and the limited spectral signal-to-noise ratio (SNR) and dispersion at clinical field In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate DehydrogenaseMutated Gliomas: A Technical Review for Neuroradiologists Hyeonjin Kim, PhD 2, , Sungjin Kim, MS, Hyeong Hun Lee, BS, Hwon Heo, PhD Department of Radiology, Seoul National University Hospital, Seoul 03080, Korea; Department of Biomedical Sciences, Seoul National University, Seoul 03087, Korea; Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul 03080, Korea