The predictor for platelet recovery after PBSCT

OBJECTIVE: In order to find out a predictor more accurate, reliable and convenient for platelet recovery capacity after peripheral blood stem cell transplantation (PBSCT). METHODS: The number of megakaryocyte progenitor cells in PBSC grafts of 17 patients with hematological malignancies or solid tumors was measured by clonogenic (CFU-MK) and flow cytometric assays. RESULTS: 1. The expression of platelet membrane glycoprotein was on < 5% of CD34+ cells. 2. The time needed for platelet recovery was better correlated with the number of CD34+/CD41a+ cells than with the total number of CD34+ cells. 3. There was a close correlation between the number of CFU-MK and the time needed for platelet recovery. 4. Correlation was observed between the number of CD34+/CD41a+ cells and that of CFU-MK. CONCLUSION: The numbers of CD34+/CD41a+ cells and CFU-MK are predictors for platelet recovery after PBSCT, but the former may be a more convenient and reliable marker for clinical study.