PREVENTION OF HEPATOTOXICITY BY MADHUCA INDICA HYDRO ALCOHOLIC AND ETHANOLIC LEAF EXTRACT IN PARACETAMOL INDUCED RAT

Present study is based on the study of Madhuca indica that is also known as mahua in different parts of the country belonging to the family Sapotaceae. It is having several medicinal properties. The leaves of Mahua tree contain saponin, an alkaloid, and glucoside. Sapogenin and other basic acid are found in the seeds. Various Photochemical studies on Mahua include characterization of Sapogenin, triterpenoids, steroids, saponin, flavonoids and glycosides. Madhuca indica has several pharmacological activity, and potential to provide health to the society. It is used as Anti diabetic, antiulcer, hepato protective, anti pyretic, anti fertility, analgesic, anti oxidant, swelling, inflammation, piles, emetic, dermatological, laxative, tonic, anti burn, anti earth worm, wound healing headache and many more problems. The leaf extract of Madhuca indica at 200 mg/kg and 400 mg/kg produce significant hepatoprotective effect against paracetamol induced hepatotoxicity. Different parameters such as physical, Histopathological and biochemical studies like ALT, SGOT, SGPT, bilirubin test had been included in the study which provides the satisfactory data to conclude the hepatoprotective effects of Madhuca indica.