Speed of Onset and Efficacy of Zolmitriptan Nasal Spray in the Acute Treatment of Migraine A Randomised, Double-Blind, Placebo-Controlled, Dose-Ranging Study versus Zolmitriptan Tablet

Objective: Zolmitriptan oral tablet is highly effective and well tolerated in the acute treatment of migraine with and without aura in adults. A nasal spray formulation has now been developed. The objective of this study was to compare the efficacy and tolerability of fixed doses of zolmitriptan administered via a nasal spray with placebo and zolmitriptan oral tablet in the acute treatment of migraine.