Selective Synthesis of Pyrazolo[3,4-d]pyrimidine, N-(1H-Pyrazol-5-yl)formamide, or N-(1H-Pyrazol-5-yl)formamidine Derivatives from N-1-Substituted-5-aminopyrazoles with New Vilsmeier-Type Reagents.

Chun-Hsi Chang,Henry J. Tsai,Yu-Ying Huang,Hui-Yi Lin,Li-Ya Wang,Tian Shung Wu,Fung Fuh Wong

Selective Synthesis of Pyrazolo[3,4-d]pyrimidine, N-(1H-Pyrazol-5-yl)formamide, or N-(1H-Pyrazol-5-yl)formamidine Derivatives from N-1-Substituted-5-aminopyrazoles with New Vilsmeier-Type Reagents.

2013

Chun-Hsi Chang
Henry J. Tsai
Yu-Ying Huang
Hui-Yi Lin
Li-Ya Wang
Tian Shung Wu
Fung Fuh Wong

The direction of reaction of aminopyrazoles (I) with N-methylformamide or formamide in the presence of POCl3 depends on the structure of starting compound (I) and Vilsmeier reagent used.

Keywords:

Formamide
Pyrimidine
Chemistry
Reagent
Organic chemistry

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