Synthesis, Characterization and Biological Activities of Novel a 1,2,3,4-tetrahydroquinazoline and Its Nickel(II) Complexes

The 2-methyl-2-(1-hydroxyiminoethyl)-1,2,3,4-tetrahydroquinazoline (HL or 1 ) and its novel Ni(II) complexes, square-planar [Ni(L)(LH)]·(NO 3 ) ( 2 ) and octahedral [NiCl 2 (LH)(H 2 O) 2 ]·(H 2 O) ( 3 ), have been synthesized. The ligand and complexes have been characterized by means of elemental, IR, UV-Vis. spectroscopic studies, 1 H-NMR, 13 C-NMR, magnetic susceptibility, thermal analysis, mass spectroscopy and X-ray diffraction technique. The HL ligand crystallizes in the P2 1 /c. Antimicrobial activity of ligand ( 1 ) and complexes ( 2 and 3 ) was evaluated by the agar diffusion method. Complex 2 showed weak antimicrobial activity against tested microorganism strains. Complex 3 exhibited moderate antimicrobial activity against Staphylococcus epidermidis and Candida albicans.