A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

John F. Peden,Jemma C. Hopewell,Danish Saleheen,John Chambers,Jörg Hager,Nicole Soranzo,Rory Collins,John Danesh,Paul Elliott,Martin Farrall,Kathy Stirrups,Weihua Zhang,Anders Hamsten,S Parish,Mark Lathrop,Hugh Watkins,Robert Clarke,Panos Deloukas,Jaspal S. Kooner,Anuj Goel,Halit Ongen,Rona J. Strawbridge,Simon C. Heath,Anders Mälarstig,Anna Helgadottir,John Öhrvik,Muhammed Murtaza,Simon Potter,Sarah Hunt,Marc Delepine,Shapour Jalilzadeh,Tomas Axelsson,Ann-Christine Syvänen,Rhian Gwilliam,Suzannah Bumpstead,Emma Gray,Sarah Edkins,Lasse Folkersen,Theodosios Kyriakou,Anders Franco-Cereceda,Anders Gabrielsen,Udo Seedorf,Per Eriksson,Alison Offer,Louise Bowman,Peter Sleight,Jane Armitage,Richard Peto,Gonçalo R. Abecasis,Nabeel Ahmed,Mark J. Caulfield,Peter Donnelly,Philippe Froguel,Angad S. Kooner,Mark McCarthy,Nilesh J. Samani,James Scott,Joban Sehmi,Angela Silveira,Mai-Lis Hellénius,Ferdinand M. van't Hooft,Gunnar Olsson,Stephan Rust,Gerd Assmann,Simona Barlera,Gianni Tognoni,Maria Grazia Franzosi,Pamela Linksted,Fiona Green,Asif Rasheed,Moazzam Zaidi,Nabi Shah,Maria Samuel,Nadeem Hayat Mallick,Muhammad Azhar,Khan Shah Zaman,Abdus Samad,Mohammad Ishaq,Ali Raza Gardezi,Fazal-ur-Rehman Memon,Philippe Frossard,Tim D. Spector,Leena Peltonen,Markku S. Nieminen,Juha Sinisalo,Veikko Salomaa,Samuli Ripatti,Derrick Bennett,Karin Leander,Bruna Gigante,Ulf de Faire,Silvia Pietri,Francesca Gori,Roberto Marchioli,Suthesh Sivapalaratnam,John J. P. Kastelein,Mieke D. Trip,Eirini V. Theodoraki,George Dedoussis,Jc Engert,Salim Yusuf,Sonia S. Anand

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

2011

John F. Peden
Jemma C. Hopewell
Danish Saleheen
John Chambers
Jörg Hager
Nicole Soranzo
Rory Collins
John Danesh
Paul Elliott
Martin Farrall
Kathy Stirrups
Weihua Zhang
Anders Hamsten
S Parish
Mark Lathrop
Hugh Watkins
Robert Clarke
Panos Deloukas
Jaspal S. Kooner
Anuj Goel
Halit Ongen
Rona J. Strawbridge
Simon C. Heath
Anders Mälarstig
Anna Helgadottir
John Öhrvik
Muhammed Murtaza
Simon Potter
Sarah Hunt
Marc Delepine
Shapour Jalilzadeh
Tomas Axelsson
Ann-Christine Syvänen
Rhian Gwilliam
Suzannah Bumpstead
Emma Gray
Sarah Edkins
Lasse Folkersen
Theodosios Kyriakou
Anders Franco-Cereceda
Anders Gabrielsen
Udo Seedorf
Per Eriksson
Alison Offer
Louise Bowman
Peter Sleight
Jane Armitage
Richard Peto
Gonçalo R. Abecasis
Nabeel Ahmed
Mark J. Caulfield
Peter Donnelly
Philippe Froguel
Angad S. Kooner
Mark McCarthy
Nilesh J. Samani
James Scott
Joban Sehmi
Angela Silveira
Mai-Lis Hellénius
Ferdinand M. van't Hooft
Gunnar Olsson
Stephan Rust
Gerd Assmann
Simona Barlera
Gianni Tognoni
Maria Grazia Franzosi
Pamela Linksted
Fiona Green
Asif Rasheed
Moazzam Zaidi
Nabi Shah
Maria Samuel
Nadeem Hayat Mallick
Muhammad Azhar
Khan Shah Zaman
Abdus Samad
Mohammad Ishaq
Ali Raza Gardezi
Fazal-ur-Rehman Memon
Philippe Frossard
Tim D. Spector
Leena Peltonen
Markku S. Nieminen
Juha Sinisalo
Veikko Salomaa
Samuli Ripatti
Derrick Bennett
Karin Leander
Bruna Gigante
Ulf de Faire
Silvia Pietri
Francesca Gori
Roberto Marchioli
Suthesh Sivapalaratnam
John J. P. Kastelein
Mieke D. Trip
Eirini V. Theodoraki
George Dedoussis
Jc Engert
Salim Yusuf
Sonia S. Anand

Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). ...

Keywords:

Genetic association
Locus (genetics)
Genetics
Heritability
Coronary artery disease
Genome-wide association study
Biology
south asia

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