LONGITUDINAL, MULTI-MODALITY, MRI STUDIES OF GAMMA-SECRETASE INHIBITION IN AN APP-SW MOUSE MODEL OF ALZHEIMER'S DISEASE

STUDIESOFGAMMA-SECRETASE INHIBITION IN AN APP-SW MOUSE MODEL OFALZHEIMER’S DISEASE Barry J. Bedell, Simone P. Zehntner, Thomas Rosahl, Kathleen Wood, Kelly R. Bales, Michael A. Marconi, Eric Parker, Felix Carbonell, Alex P. Zijdenbos, Biospective Inc. & McGill University, Montreal, Quebec, Canada; Biospective Inc., Montreal, Quebec, Canada; Merck & Co., Rahway, New Jersey, United States; Pfizer Inc., Cambridge, Massachusetts, United States; 5 Merck Research Laboratories, Kenilworth, New Jersey, United States. Contact e-mail: bbedell@biospective.com