Drug target proteins and target genes, as well as screening methods

An object of the present invention is to provide a target protein and a target gene of a physiologically active substance such as a drug, and a means capable of developing a novel physiologically active substances using these. The present invention, target proteins and target genes of physiologically active substances; complex comprising a physiologically active substance and a target protein; method for producing a physiologically active substance derivative; regulators of physiological activity; screening method for a substance capable of regulating a physiological activity , and the method for manufacturing a composite; used in the determination method of the onset or risk of a given disease or condition, determining how sensitivity to a physiologically active substance, and the determination method; and the physiologically active substance or a kit containing the salt to provide such determination kit.