A Facile synthesis of substituted quinolines by NaH mediated benzylic C-H functionalization of methyl aza-arenes and nucleophilic addition to aromatic aldehydes

A method for synthesizing condensed quinolines by using NaH catalyzed A mixture of substituted methyl quinolines and Various aromatic aldehydes in the presence of THF solvents were successfully synthesized in excellent yields via C-C single bond formation. The quinoline ring derivatives widely used as has been found to possess antimalarial, anti-bacterial, antifungal, anthelmintic, cardiotonic, anticonvulsant, anti-inflammatory, and analgesic activity.