Synthesis and NF-κB Inhibitory Activities of N-Substituted-aryl-3-phenylpropanamide Derivatives
2015
A series of N-substitutedaryl-3-phenylpropanamide derivatives were synthesized and their inhibitory activities on LPS-induced NF-κB transcriptional activity on RAW 264.7 cells were evaluated. Cl substituted derivatives (1e, 1f) have shown more potent activities than parent hit compound KL-1156.
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