Synthesis of Silver Nanoparticles and Therapeutic Films for Ophthalmology Based on Them

This article presents the results of the silver nanoparticles synthesis by a simple and ecological method of chemical reduction of silver from silver nitrate in an aqueous solution of sodium citrate and their use in the treatment of eye diseases. The technological conditions that lead to formation of silver nanoparticles with spherical shape and size of 30 nm with an intensive band of surface plasmon resonance are established. The effect of the application of therapeutic films with nanoparticles on the ultrastructure of the epithelium and stroma of the cornea of a rabbit after modeling in animals of moderately severe bacterial keratitis has been studied. It has been established that the application of therapeutic films with silver nanoparticles, as compared with antibiotics, leads to more efficient regeneration of the anterior corneal epithelium, contributes to the rapid restoration of the stroma and active formation of the delicate collagen skeleton typical of healthy corneal tissue.