Paroxysmal Nocturnal Hemoglobinuria after Autologous Stem Cell Transplantation: Extinction of the Clone during Treatment with Eculizumab – Pathophysiological Implications of a Unique Clinical Case

Stefano Pulini,Ludovica Marando,Annalisa Natale,Caterina Pascariello,Virginia Catinella,Luigi Del Vecchio,Antonio M. Risitano,Giuseppe Fioritoni

Paroxysmal Nocturnal Hemoglobinuria after Autologous Stem Cell Transplantation: Extinction of the Clone during Treatment with Eculizumab – Pathophysiological Implications of a Unique Clinical Case

2011

Stefano Pulini
Ludovica Marando
Annalisa Natale
Caterina Pascariello
Virginia Catinella
Luigi Del Vecchio
Antonio M. Risitano
Giuseppe Fioritoni

The clinical and biological spectrum of paroxysmal nocturnal hemoglobinuria (PNH) is variable, ranging from classical hemolytic forms to PNH associated with aplastic anemia or other bone marrow (BM) f

Keywords:

Medicine
Aplastic anemia
Eculizumab
Bone marrow
Immunology
Ranging
Paroxysmal nocturnal hemoglobinuria
Autologous stem-cell transplantation
Hematopoietic stem cell
Non-Hodgkin's lymphoma
Pathophysiology
Clone (cell biology)

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