Tuberous Sclerosis Complex: Skin and Heart: Pivotal Common and Early Signs

Tuberous sclerosis (TSC) is a genetic neurocutaneous disease resulting from mutation in TSC1 or TSC2 gene and associated with development of multiple tumors in different organs including skin, brain, heart, and kidney. TSC is associated with high incidence of epilepsy (70–90%) and associated with seizures cognitive impairment (50–60%). Skin and cardiac manifestations are the earliest detectable signs of TSC, facilitating diagnosis and intervention before seizures.