Az iszkémiás és posztiszkémiás vaszkuláris és kardiorespiratorikus károsodások tanulmányozása = Investigation of apparent injury in the vascular and cardiorespiratory system due to ischemia and reperfusion

((1) A szivhipertrofiat iranyito GATA-4 transzkripcios faktort a mitogen-aktivalta protein kinazok (p38, ERK) aktivaljak mechanikai feszites soran. (2) Kamrai falfeszules az endogen endothelin-1 es az angiotenzin II reven valtja ki a BNP expressziojanak fokozodasat. (3) Az endogen ouabain-szerű anyag szerepet jatszik az ANP bal kamrai genexpressziojanak szabalyozasaban. (4) A nuklearis faktor-kappaB transzkripcios faktor gatlasa kivedi a bal kamrai remodellinget annak előrehaladott fazisaban. (5) A szivizom-kontraktilitas szabalyozasaban dontő szerepet jatszanak a mitogen aktivalta protein kinazok. (6) Viabilitas, coronaria occlusios idő okozta bal kamra funkcio valtozas vizsgalata MRI-vel. Az occlusios idő 45 es 90 perc kozott valtoztatvan proporcionalisan rontotta a bal kamra funkciot, mely mogott okkent az aranyos infarctus meret all. (7) Human mitrokondriumok nem termelnek relevans mennyisegű nitrogen oxidot iszkemias szivbetegekben. (8) A flavonoid szupplementacio előnyos hatasu kronikus obstruktiv tudőbetegsegben. (9) Invaziv modon validaltuk az arterias stifness meghatarozasara szolgalo non-invaziv Arteriograf keszuleket. (10) Jellemeztuk a szerum asszimmetrikus dimetil-arginin valtozasat kateteres revascularizatios eljarason atesett betegeknel. (11) A poli-ADP-riboz polimeraz enzim gatlasa javitja a bal kamrai funkciot akut es kronikus experimentalis szivelegtelensegben. (12) A szivritmus variabilitas vizsgalatara hatekony elemző rendszert fejlesztettunk ki. | (1) Our results suggest that the prohypertrophic transcription factor GATA-4 is activated by mitogen-activated protein kinases (p38, ERK) in response to mechanical stretch. (2) Stretch-induced activation of B-type natriuretic peptid gene expression is regulated by endogenous endothelin-1 and angiotensin II. (3) Adrenal-derived endogenous ouabain-like compound is involved in the activation of atrial natriuretic peptide in the left ventricle. (4) Inhibition of nuclear factor kappa-B attenuates severe left ventricular remodeling. (5) Mitogen-activated protein kinases play pivotal role in the regulation of myocardial contractility. (6) MRI study of LV function: dependence on coronary occlusion time and viability. Occlusion time between 45 and 60 minutes induced larger infarct and consequent heart failure proportionally. (7) Human heart mitochondria do not produce physiologically relevant quantities of nitric oxide. (8) Dietary flavonoids are beneficial in chronic obstructive pulmonary disease. (9) A new, oscillometric, portable device for measuring augmentation index and aortic pulse wave velocity (Areteriograph) has been validated invasively. (10) The response of asymetric dimethylarginine levels to stent placement has been characterized in patients with coronary heart disease. (11) Inhibition of poly(ADP-ribose) polymerase improves cardiac function in acute and chronic heart failure. (12) A data analysis system has been developed for analysis of heart rate variability.