Pot, Atom and Step Economic (PASE) Synthesis of 2-Amino-3, 5-Dicarbonitrile-6-Thio-Pyridines in Aqueous PEG-400 Promoted by Sodium Benzoate

An efficient pot, atom and step economic (PASE), sodium benzoate promoted synthesis of 2-amino pyridine-3, 5 dicarbonitriles by the reaction of aldehydes, malonitrile and thiophenol in PEG-400 in water is reported. This new protocol has the advantages of convenient procedure, eco-friendliness, shorter reaction times and higher yields.